The present study assessed the bioremediation potential of <em>Fusarium chlamydosporium</em> SPFS2-g isolated from tannery effluent enriched soil. The isolate exhibited minimum inhibitory concentration (MIC) for Cr(VI) as 500 ppm. The treatment of tannery wastewater with <em>Fusarium chlamydosporium</em> in shake flask experiment resulted in the reduction of chemical oxygen demand (COD), color, Cr(VI), &nbsp;total suspended solids (TSS), turbidity, Na⁺, Cl^-, and NO₃^- in the order of 71.80, 64.69, 100, 36.47, 22.77, 11.69, 27.87 and 62.33%, respectively after six days of treatment duration.