<p><span style="font-size:14px"><span style="font-family:Arial,Helvetica,sans-serif">The purpose of this article is to analyze integrated wastewater treatment plant (WWTP) design for Tanjung Api-Api (TAA) agro-industrial area, South Sumatra, Indonesia, using Environmentally Sensitive Investment System (ESIS). This article is based on empirical research that conducted in Banyuasin District, South Sumatera Province, Indonesia. Our result show that wastewater discharge (Q) release into river at E5 has reachton/day and contain 87.16 mg/l TSS. This number does not exceed200 mg/l, TSS threshold for industry area, which regulated by South Sumatra Province through Regulation of the Governor of South Sumatera 18/2005 on Liquid Waste Quality Standard (LWQS). It also produced BOD (100 mg/l) lower than LQWS standard (200 mg/l). Sludge dewatering generate 724,48mg/l/day TSS which can be converted into value-added product. Our WWTP design for TAA area can protect wetland ecosystems in South Sumatra Province. We also give recommendation for TAA multi-stakeholder and propose several topics for further research.</span></span></p>